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Brinkman Lab
Microbe-loving bioinformatics and genomics research lab, aiming to better control infectious diseases and associated immune disorders in a sustainable way.
Infectious disease control needs to be made more 鈥渟ustainable鈥. We need to reduce selective pressure on pathogens to evolve antibiotic resistance. We need to control infectious disease outbreaks and associated immune disorders with a better understanding of the genetic, environmental and social factors that impact disease spread and severity.
The Brinkman laboratory is developing bioinformatics methods, and capitalizing on combined bioinformatics and wet-lab approaches, investigating microbes and their host/environmental interactions, to better understand key themes in infectious disease etiology, microbiome conservation, and associated immune disorders. The overall goal is to develop more sustainable, integrated approaches for disease control.
For more details, visit our .
Email:
FIONA BRINKMAN
brinkman@sfu.ca
LAB ROOM:
SSB 7165
SSB 7121
ASB 10936
LAB PHONE:
(778) 782-5414
Selected Publications
- Gill EE, Jia B, Murall CL, Poujol R, Anwar MZ, John NS, Richardsson J, Hobb A, Olabode AS, Lepsa A, Duggan AT, Tyler AD, N'Guessan A, Kachru A, Chan B, Yoshida C, Yung CK, Bujold D, Andric D, Su E, Griffiths EJ, Van Domselaar G, Jolly GW, Ward HKE, Feher H, Baker J, Simpson JT, Uddin J, Ragoussis J, Eubank J, Fritz JH, G谩lvez JH, Fang K, Cullion K, Rivera L, Xiang L, Croxen MA, Shiell M, Prystajecky N, Quirion PO, Bajari R, Rich S, Mubareka S, Moreira S, Cain S, Sutcliffe SG, Kraemer SA, Alturmessov Y, Joly Y, Cphln Consortium, CanCOGeN Consortium, VirusSeq Data Portal Academic And Health Network, Fiume M, Snutch TP, Bell C, Lopez-Correa C, Hussin JG, Joy JB, Colijn C, Gordon PMK, Hsiao WWL, Poon AFY, Knox NC, Courtot M, Stein L, Otto SP, Bourque G, Shapiro BJ, Brinkman FSL. (2024). The Canadian VirusSeq Data Portal & Duotang: open resources for SARS-CoV-2 viral sequences and genomic epidemiology. Microb. Genomics; n10:001293.
- Lau WYV+, Taylor PK+, Brinkman FSL*, Lee AHY* (2023). Pathogen-associated gene discovery workflows for novel antivirulence therapeutic development. EBioMedicine: The Lancet Discovery Science. 88:104429. *These authors contributed equally.
- Alcock BP, Huynh W, Chalil R, Smith KW, Raphenya AR, Wlodarski MA, Edalatmand A, Petkau A, Syed SA, Tsang KK, Baker SJC, Dave M, McCarthy MC, Mukiri KM, Nasir JA, Golbon B, Imtiaz H, Jiang X, Kaur K, Kwong M, Liang ZC, Niu KC, Shan P, Yang JYJ, Gray KL, Hoad GR, Jia B, Bhando T, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM, Bordeleau E, Dooley D, Griffiths E, Zubyk HL, Brown ED, Maguire F, Beiko RG, Hsiao WWL, Brinkman FSL, Van Domselaar G, McArthur AG (2023). CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database. Nucleic Acids Res. 51:D690-D699. doi: 10.1093/nar/gkac920.
- Bertelli C, Gray KL, Woods N, Lim AC, Tilley KE, Winsor GL, Hoad GR, Roudgar A, Spencer A, Peltier J, Warren D, Raphenya AR, McArthur AG, Brinkman FSL (2022). Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks. Microb Genom. 8:mgen000818. doi: 10.1099/mgen.0.000818.
- Almblad H, Randall TE, Liu F, Leblanc K, Groves RA, Kittichotirat W, Winsor GL, Fournier N, Au E, Groizeleau J, Rich JD, Lou Y, Granton E, Jennings LK, Singletary LA, Winstone TML, Good NM, Bumgarner RE, Hynes MF, Singh M, Stietz MS, Brinkman FSL, Kumar A, Brassinga AKC, Parsek MR, Tseng BS, Lewis IA, Yipp BG, MacCallum JL, Harrison JJ (2021). Bacterial cyclic diguanylate signaling networks sense temperature. Nature Communications 12:1986. doi: 10.1038/s41467-021-22176-2.
- Lau WYV, Hoad GR, Jin V, Winsor GL, Madyan A, Gray KL, Laird MR, Lo R, Brinkman FSL(2021). PSORTdb 4.0: expanded and redesigned bacterial and archaeal protein subcellular localization database incorporating new secondary localizations. Nucleic Acids Res. 49:D803-D808. doi: 10.1093/nar/gkaa1095.
- Maguire F*, Jia B*, Gray KL, Lau WYV, Beiko RG, Brinkman FSL (2020). Metagenome-assembled genome binning methods with short reads disproportionately fail for plasmids and genomic islands. Microb Genom. doi: 10.1099/mgen.0.000436. *These authors contributed equally.
- Patrick DM, Sbihi H, Dai DLY, Al Mamun A, Rasali D, Rose C, Marra F, Boutin RCT, Petersen C, Stiemsma LT, Winsor GL, Brinkman FSL, Kozyrskyj AL, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, Finlay BB, Turvey SE (2020). Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies. Lancet Respir Med. 24:S2213-2600(20)30052-7.
- McDaniel CT, Panmanee W, Winsor GL, Gill E, Bertelli C, Schurr MJ, Dongare P, Paul AT, Ko SB, Lau GW, Dasgupta N, Bogue AL, Miller WE, Mortensen JE, Haslam DB, Dexheimer P, Muruve DA, Aronow BJ, Forbes MDE, Danilczuk M, Brinkman FSL, Hancock REW, Meyer TJ, Hassett DJ (2020). AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria. Proc Natl Acad Sci U S A. 117(9):4921-4930.
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